Cortex
in sentence
196 examples of Cortex in a sentence
And you have the cerebral
cortex
providing the great spectacle of our minds with the profusion of images that are, in fact, the contents of our minds and that we normally pay most attention to, as we should, because that's really the film that is rolling in our minds.
You cannot have a conscious mind if you don't have the interaction between cerebral
cortex
and brain stem.
Except that they're not as rich as ours, because they don't have a cerebral
cortex
like we do.
And I strongly disagree with the idea that consciousness should be considered as the great product of the cerebral
cortex.
The first two are shared with many, many other species, and they are really coming out largely of the brain stem and whatever there is of
cortex
in those species.
Why care if it is the brain stem or the cerebral
cortex
and how this is made?
So just the same way that we were able to jump over the damaged circuitry in the retina to get to the retina's output cells, we can jump over the damaged circuitry in the cochlea to get the auditory nerve, or jump over damaged areas in the cortex, in the motor cortex, to bridge the gap produced by a stroke.
And indeed, you do see it in the human entorhinal cortex, which is the same part of the brain that you see grid cells in rats.
One of the brain regions that changes most dramatically during adolescence is called prefrontal
cortex.
So this is a model of the human brain, and this is prefrontal cortex, right at the front.
Prefrontal
cortex
is an interesting brain area.
The arrows indicate peak gray matter volume in prefrontal
cortex.
You can see that that peak happens a couple of years later in boys relative to girls, and that's probably because boys go through puberty a couple of years later than girls on average, and then during adolescence, there's a significant decline in gray matter volume in prefrontal
cortex.
Now that might sound bad, but actually this is a really important developmental process, because gray matter contains cell bodies and connections between cells, the synapses, and this decline in gray matter volume during prefrontal
cortex
is thought to correspond to synaptic pruning, the elimination of unwanted synapses.
You prune away the weaker branches so that the remaining, important branches, can grow stronger, and this process, which effectively fine-tunes brain tissue according to the species-specific environment, is happening in prefrontal
cortex
and in other brain regions during the period of human adolescence.
So in my lab, we bring adolescents and adults into the lab to have a brain scan, we give them some kind of task that involves thinking about other people, their minds, their mental states, their emotions, and one of the findings that we've found several times now, as have other labs around the world, is part of the prefrontal
cortex
called medial prefrontal cortex, which is shown in blue on the slide, and it's right in the middle of prefrontal
cortex
in the midline of your head.
This region is more active in adolescents when they make these social decisions and think about other people than it is in adults, and this is actually a meta-analysis of nine different studies in this area from labs around the world, and they all show the same thing, that activity in this medial prefrontal
cortex
area decreases during the period of adolescence.
And this region, the regions within the limbic system, have been found to be hypersensitive to the rewarding feeling of risk-taking in adolescents compared with adults, and at the very same time, the prefrontal cortex, which you can see in blue in the slide here, which stops us taking excessive risks, is still very much in development in adolescents.
So one part is the parietal
cortex
which is very well known to control the orientation of attention.
Children who plan their own goals, set weekly schedules, evaluate their own work build up their frontal
cortex
and take more control over their lives.
The reptilian part of our brain, which sits in the center of our brain, when it's threatened, it shuts down everything else, it shuts down the prefrontal cortex, the parts which learn, it shuts all of that down.
And you see that in humans, because of the development of the pre-frontal cortex, it's called.
And you see activity in some regions we've seen today, medial prefrontal cortex, dorsomedial, however, up here, ventromedial prefrontal cortex, anterior cingulate, an area that's involved in lots of types of conflict resolution, like if you're playing "Simon Says," and also the right and left temporoparietal junction.
It depends, of course, on what scale or what scope you want to think about, but this is an organ of surreal complexity, and we are just beginning to understand how to even study it, whether you're thinking about the 100 billion neurons that are in the
cortex
or the 100 trillion synapses that make up all the connections.
It's a little different than the way we think about brain disorders like Huntington's or Parkinson's or Alzheimer's disease where you have a bombed-out part of your
cortex.
These are scans from Judy Rapoport and her colleagues at the National Institute of Mental Health in which they studied children with very early onset schizophrenia, and you can see already in the top there's areas that are red or orange, yellow, are places where there's less gray matter, and as they followed them over five years, comparing them to age match controls, you can see that, particularly in areas like the dorsolateral prefrontal
cortex
or the superior temporal gyrus, there's a profound loss of gray matter.
It's a thought in my brain, but at the same time, it's busy secreting acetylcholine and doing all sorts of other things as it makes its way from the motor
cortex
down through the nerve fibers in the arm.
They send the results of their analysis up to the auditory
cortex.
The brain stem then projects forward and bathes the cortex, this wonderfully wrinkly bit over here, with neurotransmitters that keep us awake and essentially provide us with our consciousness.
And then, as you grow up, the
cortex
develops, and inhibits these latent sexual urges towards your mother.
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