Hippocampus
in sentence
70 examples of Hippocampus in a sentence
And that structure is called the
hippocampus.
So I've always been fascinated with the
hippocampus.
I wanted to start and record the activity of individual brain cells in the
hippocampus
as subjects were forming new memories.
Let's start with my favorite brain area, the
hippocampus.
You not only get better focus and attention, but the volume of the
hippocampus
increases as well.
The more you're working out, the bigger and stronger your
hippocampus
and prefrontal cortex gets.
Because the prefrontal cortex and the
hippocampus
are the two areas that are most susceptible to neurodegenerative diseases and normal cognitive decline in aging.
So with increased exercise over your lifetime, you're not going to cure dementia or Alzheimer's disease, but what you're going to do is you're going to create the strongest, biggest
hippocampus
and prefrontal cortex so it takes longer for these diseases to actually have an effect.
This area shown here is an area called the
hippocampus.
So we'll start with the hippocampus, shown in yellow, which is the organ of memory.
The
hippocampus
is formed of two sheets of cells, which are very densely interconnected.
So we're going to imagine we're recording from a single neuron in the
hippocampus
of this rat here.
And indeed, on the inputs to the hippocampus, cells are found which project into the hippocampus, which do respond exactly to detecting boundaries or edges at particular distances and directions from the rat or mouse as it's exploring around.
Now grid cells are found, again, on the inputs to the hippocampus, and they're a bit like place cells.
I have read that there's now actually evidence that the hippocampus, the part of our brain that handles spacial relationships, physically shrinks and atrophies in people who use tools like GPS, because we're not exercising our sense of direction anymore.
Now one brain region that would be robustly active in particular is called the hippocampus, which for decades has been implicated in processing the kinds of memories that we hold near and dear, which also makes it an ideal target to go into and to try and find and maybe reactivate a memory.
XL: When you zoom in into the hippocampus, of course you will see lots of cells, but we are able to find which cells are involved in a particular memory, because whenever a cell is active, like when it's forming a memory, it will also leave a footprint that will later allow us to know these cells are recently active.
SR: So here is what the
hippocampus
looks like after forming a fear memory, for example.
Now with our system, the cells that are active in the
hippocampus
in the making of this memory, only those cells will now contain channelrhodopsin.
But then, in the 1990s, studies starting showing, following the lead of Elizabeth Gould at Princeton and others, studies started showing the evidence of neurogenesis, the birth of new brain cells in the adult mammalian brain, first in the olfactory bulb, which is responsible for our sense of smell, then in the
hippocampus
involving short-term memory, and finally in the amygdala itself.
So, like, hi guys, it's me, Bella, and I am, like, being interviewed right now for this, like, really amazing Bio-Empathetic Resonance Technology, which is, like, basically where they are, like, recording, as you can see from these, whatever, like, electrodes, the formation of, like, neuropeptides in my hippocampus, or whatever.
In order to become lasting memories, these sensory experiences have to be consolidated by the hippocampus, influenced by the amygdala, which emphasizes experiences associated with strong emotions.
The
hippocampus
then encodes memories, probably by strengthening the synaptic connections stimulated during the original sensory experience.
The amygdala prompts your
hippocampus
to consolidate the stress-inducing experience into a memory.
Meanwhile, the flood of corticosteroids from stress stimulates your hippocampus, also prompting memory consolidation.
And the weeks, months, or even years of sustained corticosteroids that result from chronic stress can damage the
hippocampus
and decrease your ability to form new memories.
And if we slice through the
hippocampus
and zoom in, what you actually see here in blue is a newborn neuron in an adult mouse brain.
And in the lab we have shown that if we block the ability of the adult brain to produce new neurons in the hippocampus, then we block certain memory abilities.
Yes, stress will decrease the production of new neurons in the
hippocampus.
And here you see a section of the
hippocampus
of a mouse that had no running wheel in its cage.
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