Chromosome in sentence

63 examples of Chromosome in a sentence

And now mind you, in a diploid organism like people, we've got one copy of our genome from our mom and one from our dad, so if one gets damaged, it can use the other chromosome to repair it.

And those keep the shoelace, or the chromosome, from fraying, and when that tip gets too short, it falls off, and that worn down telomere sends a signal to the cells.

They have a mix of chromosome types with X, with XY or with XXX.

The Y chromosome, the piece of DNA that makes men men, traces a purely paternal line of descent.

This was an African man who gave rise to all the Y chromosome diversity around the world.

Let's now start using a telescope version, but instead of using a telescope, let's use a microscope to zoom in on the inferior of those chromosomes, which is the Y chromosome.

There are exciting new forms of gene therapy that overcome the problem of placing the genetic material in the right place on the chromosome.

I've wanted to ask Craig Venter if it would be possible to insert a synthetic chromosome into a human so that we could reiterate ourselves if we wanted to.

The only way to prove these ideas was to construct an artificial chromosome with those genes in them, and we had to do this in a cassette-based fashion.

So we're now making several dozen different constructs, because we can vary the cassettes and the genes that go into this artificial chromosome.

We start with these fragments, and then we have a homologous recombination system that reassembles those into a chromosome.

The chromosome is literally blown apart.

It's on the X chromosome.

But for a son, he can only get the X chromosome from his mother.

What this means is that one of the two copies of chromosome number 15 that I have in each of my cells has a genetic mutation.

She was missing a chunk of her fourth chromosome.

And what you can do now is, you can outlay exactly what your chromosome is, and what the gene code on that chromosome is right here, and what those genes code for, and what animals they code against, and then you can tie it to the literature.

We're here today to announce the first synthetic cell, a cell made by starting with the digital code in the computer, building the chromosome from four bottles of chemicals, assembling that chromosome in yeast, transplanting it into a recipient bacterial cell and transforming that cell into a new bacterial species.

We decided early on that we had to take a synthetic route, even though nobody had been there before, to see if we could synthesize a bacterial chromosome so we could actually vary the gene content to understand the essential genes for life.

So once we realized that we could make 5,000-base pair viral-sized pieces, we thought, we at least have the means then to try and make serially lots of these pieces to be able to eventually assemble them together to make this mega base chromosome.

Carole Lartigue led the effort to actually transplant a bacterial chromosome from one bacteria to another.

In 2008, we reported the complete synthesis of the Mycoplasma genitalium genome, a little over 500,000 letters of genetic code, but we have not yet succeeded in booting up that chromosome.

So in addition to doing the transplant, we had to find out how to get a bacterial chromosome out of the eukaryotic yeast into a form where we could transplant it into a recipient cell.

So we took the same mycoides genome that Carole had initially transplanted, and we grew that in yeast as an artificial chromosome.

When we did these experiments, though, we could get the chromosome out of yeast but it wouldn't transplant and boot up a cell.

So what we found is if we took the chromosome out of yeast and methylated it, we could then transplant it.

So last fall when we published the results of that work in Science, we all became overconfident and were sure we were only a few weeks away from being able to now boot up a chromosome out of yeast.

Because of the problems with Mycoplasma genitalium and its slow growth about a year and a half ago, we decided to synthesize the much larger chromosome, the mycoides chromosome, knowing that we had the biology worked out on that for transplantation.

And Dan led the team for the synthesis of this over one-million-base pair chromosome.

So, we thought the worst problem would be a single molecule contamination of the native chromosome, leading us to believe that we actually had created a synthetic cell, when it would have been just a contaminant.

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