Genome
in sentence
369 examples of Genome in a sentence
And in particular, you've probably all heard the analogy that the
genome
is like the blueprint of your body, and if that were only true, it would be great, but it's not.
So if I look at a person and I look at a person's genome, it's the same thing.
The part of the
genome
that we can read is the list of ingredients.
So the
genome
really tells you much more about predisposition.
And in fact, thanks to Kary Mullis, you can basically measure your
genome
in your kitchen with a few extra ingredients.
And so by reading the genome, we can find out much more about your family than you probably know.
Just like
genome
mixes the study of all the genes, proteomics is the study of all the proteins.
And very importantly, with the introduction of sexual reproduction that passes on the genome, the rest of the body becomes expendable.
Evolution is all about passing on the
genome
to the next generation, adapting and surviving through generation after generation.
Today, you can have a complete sequence of the three billion base pairs in the human
genome
at a cost of about 20,000 dollars and in the space of about a week.
It won't be very long before the reality will be the 1,000-dollar human genome, and it will be increasingly available for everyone.
In genomics now, the
genome
cost about a billion dollars about 10 years ago, when the first one came out.
We're now approaching essentially a $1,000 genome, probably next year.
And in two years, a $100
genome.
If we compare my
genome
to the
genome
of you, approximately every 1,200, 1,300 letters will differ between us.
And if you're then interested in the history of a piece of DNA, or the whole genome, you can reconstruct the history of the DNA with those differences you observe.
So we can now, in a matter of hours, determine a whole human
genome.
And we will find that the two genomes in me, or one
genome
of mine we want to use, will have about three million differences in the order of that.
It means that when we look at people and see a person from Africa and a person from Europe or Asia, we cannot, for a single position in the
genome
with 100 percent accuracy, predict what the person would carry.
And this then, in conjunction with these methods that allow very many DNA molecules to be sequenced very rapidly, allowed us last year to present the first version of the Neanderthal genome, so that any one of you can now look on the Internet, on the Neanderthal genome, or at least on the 55 percent of it that we've been able to reconstruct so far.
If they then mixed with each other there, then those modern humans that became the ancestors of everyone outside Africa carried with them this Neanderthal component in their
genome
to the rest of the world.
So having now a Neanderthal
genome
on hand as a reference point and having the technologies to look at ancient remains and extract the DNA, we can begin to apply them elsewhere in the world.
And it was well enough preserved so we could determine the DNA from this individual, even to a greater extent than for the Neanderthals actually, and start relating it to the Neanderthal
genome
and to people today.
If we ask that question, and compare the Denisovan
genome
to people around the world, we surprisingly find no evidence of Denisovan DNA in any people living even close to Siberia today.
Does this then mean that there is after all some absolute difference between people outside Africa and inside Africa in that people outside Africa have this old component in their
genome
from these extinct forms of humans, whereas Africans do not?
And since we mixed elsewhere, I'm pretty sure that one day, when we will perhaps have a
genome
of also these earlier forms in Africa, we will find that they have also mixed with early modern humans in Africa.
You can decode the genome, you can look back, you can link us all together by a mitochondrial DNA, but we can't get further than the last ancestor, the last visible cell that we could sequence or think back in history.
Ladies and gentlemen, I present to you the human
genome.
But in fact, if I were to place one base on each pixel of this 1280x800-resolution screen, we would need 3,000 screens to take a look at the
genome.
And so 15 years, actually, and about four billion dollars later, the
genome
was sequenced and published.
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