Chromosome
in sentence
63 examples of Chromosome in a sentence
And in this scenario, I want to imagine that, in one case, the sperm is carrying a Y chromosome, meeting that X
chromosome
of the egg.
And in the other case, the sperm is carrying an X chromosome, meeting the X
chromosome
of the egg.
So in one instance, you can have somebody who has an XY chromosomal basis, and that SRY gene on the Y
chromosome
tells the proto-gonads, which we all have in the fetal life, to become testes.
And they do some tests and figure out that, instead of having ovaries inside and a uterus, she has testes inside, and she has a Y
chromosome.
So for example, Texas has at one point decided that what it means to marry a man is to mean that you don't have a Y chromosome, and what it means to marry a woman means you have a Y
chromosome.
Women have two copies of that big X chromosome; men have the X and, of course, that small copy of the Y. Sorry boys, but it's just a tiny little thing that makes you different.
This huge package of DNA is called a
chromosome.
When the cell feels it's ready to go, it rips apart the
chromosome.
And if we isolate just one chromosome, we're going to pull it out and have a look at its structure.
So this is a single
chromosome.
It's able to feel when the cell is ready, when the
chromosome
is correctly positioned.
Cystic fibrosis had its molecular cause discovered in 1989 by my group working with another group in Toronto, discovering what the mutation was in a particular gene on
chromosome
7.
Well, one way to go faster is to take advantage of technology, and a very important technology that we depend on for all of this is the human genome, the ability to be able to look at a chromosome, to unzip it, to pull out all the DNA, and to be able to then read out the letters in that DNA code, the A's, C's, G's and T's that are our instruction book and the instruction book for all living things, and the cost of doing this, which used to be in the hundreds of millions of dollars, has in the course of the last 10 years fallen faster than Moore's Law, down to the point where it is less than 10,000 dollars today to have your genome sequenced, or mine, and we're headed for the $1,000 genome fairly soon.
But we've come up with very clever ways that we can actually discriminate, capture and discriminate, the mammoth from the non-mammoth DNA, and with the advances in high-throughput sequencing, we can actually pull out and bioinformatically re-jig all these small mammoth fragments and place them onto a backbone of an Asian or African elephant
chromosome.
So we decided the only way forward was to actually synthesize this
chromosome
so we could vary the components to ask some of these most fundamental questions.
And so we started down the road of: can we synthesize a
chromosome?
And if we do, can we boot up a
chromosome?
A chromosome, by the way, is just a piece of inert chemical material.
You can see in the top panel, its
chromosome
just gets blown apart.
Well, how do we boot up a
chromosome?
With bacteria and Archaea, the
chromosome
is integrated into the cell, but we recently showed that we can do a complete transplant of a
chromosome
from one cell to another and activate it.
The new
chromosome
went into the cell.
We find all kinds of species that have taken up a second
chromosome
or a third one from somewhere, adding thousands of new traits in a second to that species.
The
chromosome
that was in the cell doesn't have one; the
chromosome
we put in does.
It got expressed and it recognized the other
chromosome
as foreign material, chewed it up, and so we ended up just with a cell with the new
chromosome.
And thankfully, scientists like Dr. Page from the Whitehead Institute, who works on the Y chromosome, and Doctor Yang from UCLA, they have found evidence that tells us that those sex-determining chromosomes that are in every cell in our bodies continue to remain active for our entire lives and could be what's responsible for the differences we see in the dosing of drugs, or why there are differences between men and women in the susceptibility and severity of diseases.
Once those bits of DNA have been inserted into the bacterial chromosome, the cell then makes a little copy of a molecule called RNA, which is orange in this picture, that is an exact replicate of the viral DNA.
You see, for most mammals, the sex of a baby is determined genetically with the XY
chromosome
system.
However, in these animals, one Z and one W
chromosome
together, as a pair, produces a female.
Now in the nature area, we look at whether or not we are innately equipped with something, perhaps in our brains, some abnormal
chromosome
that causes this muse-like effect.
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