Telomeres
in sentence
45 examples of Telomeres in a sentence
That's because it has even been associated with shortened telomeres, the shoelace tip ends of chromosomes that measure a cell's age.
When
telomeres
become too short, a cell can no longer divide and it dies.
The DNA in our cells is packaged within chromosomes, each of which has two protective regions at the extremities called
telomeres.
When
telomeres
become too short, cells stop replicating and die, slowing the body's ability to renew itself.
And it was because I was curious about the very ends of chromosomes, known as
telomeres.
And it so happens that cute little Tetrahymena has a lot of short linear chromosomes, around 20,000, so lots of
telomeres.
And I discovered that
telomeres
consisted of special segments of noncoding DNA right at the very ends of chromosomes.
Their
telomeres
weren't shortening as time marched on.
It was a previously undreamed-of enzyme that could replenish, make longer, telomeres, and we named it telomerase.
And when we removed our pond scum's telomerase, their
telomeres
ran down and they died.
OK, now, that's an incredibly hopeful message for us humans to be receiving from pond scum, because it turns out that as we humans age, our
telomeres
do shorten, and remarkably, that shortening is aging us.
Generally speaking, the longer your telomeres, the better off you are.
It's the overshortening of
telomeres
that leads us to feel and see signs of aging.
Our
telomeres
are losing the war of attrition faster.
And those of us who feel youthful longer, it turns out our
telomeres
are staying longer for longer periods of time, extending our feelings of youthfulness and reducing the risks of all we most dread as the birthdays go by.
Now, if my
telomeres
are connected to how quickly I'm going to feel and get old, if my
telomeres
can be renewed by my telomerase, then all I have to do to reverse the signs and symptoms of aging is figure out where to buy that Costco-sized bottle of grade A organic fair trade telomerase, right?
Now, don't worry, and because, while I think it's kind of funny that right now, you know, many of us may be thinking, "Well, I'd rather be like pond scum," ... (Laughter) there is something for us humans in the story of
telomeres
and their maintenance.
So the real question becomes, OK, if I can't guzzle telomerase, do I have control over my
telomeres'
length and hence my well-being, my health, without those downsides of cancer risks?
Now, I've been minutely scrutinizing little teeny tiny
telomeres
very happily for many years, when into my lab walks a psychologist named Elissa Epel.
"What happens to
telomeres
in people who are chronically stressed?"
See, all this time I had been thinking of
telomeres
as those miniscule molecular structures that they are, and the genes that control
telomeres.
And when Elissa asked me about studying caregivers, I suddenly saw
telomeres
in a whole new light.
So was it possible their
telomeres
were worn down as well?
Elissa selected for our first study a group of such caregiving mothers, and we wanted to ask: What's the length of their
telomeres
compared with the number of years that they have been caregiving for their child with a chronic condition?
The longer, the more years that is, the mother had been in this caregiving situation, no matter her age, the shorter were her
telomeres.
And the more she perceived her situation as being more stressful, the lower was her telomerase and the shorter were her
telomeres.
So we had discovered something unheard of: the more chronic stress you are under, the shorter your telomeres, meaning the more likely you were to fall victim to an early disease span and perhaps untimely death.
Our findings meant that people's life events and the way we respond to these events can change how you maintain your
telomeres.
We noticed that some mothers, despite having been carefully caring for their children for many years, had been able to maintain their
telomeres.
So several studies rapidly confirmed our initial finding that yes, chronic stress is bad for
telomeres.
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