Chromosomes
in sentence
64 examples of Chromosomes in a sentence
He had XX chromosomes, and in the womb, his adrenal glands were in such high gear that it created, essentially, a masculine hormonal environment.
Some people who have XX
chromosomes
develop what are called ovotestis, which is when you have ovarian tissue with testicular tissue wrapped around it.
In practice they don't test people for their
chromosomes.
But before doing that, I just briefly want to remind you about what you already know: that our genomes, our genetic material, are stored in almost all cells in our bodies in
chromosomes
in the form of DNA, which is this famous double-helical molecule.
We each have 23 pairs of
chromosomes.
And on these
chromosomes
are roughly 25,000 genes.
And we'll come back to
chromosomes
in a minute.
These sausage-shaped things are the chromosomes, and we'll focus on them.
Now we're going to rewind and just focus on the chromosomes, and look at its structure and describe it.
It is obviously central to the movement of the
chromosomes.
It broadcasts through chemical signals, telling the rest of the cell when it's ready, when it feels that everything is aligned and ready to go for the separation of the
chromosomes.
And in that space station we have the genetic material, the chromosomes, within a nucleus.
As cell division begins the nucleus disintegrates, the
chromosomes
line up in the middle of the cell and those special proteins undergo a three-dimensional sequence whereby they attach and they literally click into place end-on-end to form chains.
Potatoes have 48 chromosomes, two more than people, and the same as a gorilla.
So that means that we can actually take Asian elephant chromosomes, modify them into all those positions we've actually now been able to discriminate with the mammoth genome, we can put that into an enucleated cell, differentiate that into a stem cell, subsequently differentiate that maybe into a sperm, artificially inseminate an Asian elephant egg, and over a long and arduous procedure, actually bring back something that looks like this.
We have the ability now to build a large robot that can make a million
chromosomes
a day.
And thankfully, scientists like Dr. Page from the Whitehead Institute, who works on the Y chromosome, and Doctor Yang from UCLA, they have found evidence that tells us that those sex-determining
chromosomes
that are in every cell in our bodies continue to remain active for our entire lives and could be what's responsible for the differences we see in the dosing of drugs, or why there are differences between men and women in the susceptibility and severity of diseases.
Mammals have a pair of sex chromosomes, one passed down from mom, and one from dad.
It's wound very tightly into
chromosomes
that are present in every cell of your body or in a plant's body.
And I'm going to illustrate this very crudely for maize, where the
chromosomes
below the off switch represent all the genes that are required for desiccation tolerance.
That's because it has even been associated with shortened telomeres, the shoelace tip ends of
chromosomes
that measure a cell's age.
The DNA in our cells is packaged within chromosomes, each of which has two protective regions at the extremities called telomeres.
This CRISPR gene drive that Esvelt created not only guarantees that a trait will get passed on, but if it's used in the germline cells, it will automatically copy and paste your new gene into both
chromosomes
of every single individual.
Now, for me, this little pond scum critter Tetrahymena was a great way to study the fundamental mystery I was most curious about: those bundles of DNA in our cells called
chromosomes.
And it was because I was curious about the very ends of chromosomes, known as telomeres.
Now, when I started my quest, all we knew was that they helped protect the ends of
chromosomes.
And it so happens that cute little Tetrahymena has a lot of short linear chromosomes, around 20,000, so lots of telomeres.
And I discovered that telomeres consisted of special segments of noncoding DNA right at the very ends of
chromosomes.
So every time a cell divides, all of its DNA has to be copied, all of the coding DNA inside of those chromosomes, because that carries the vital operating instructions that keep our cells in good working order, so my heart cells can keep a steady beat, which I assure you they're not doing right now, and my immune cells can fight off bacteria and viruses, and our brain cells can save the memory of our first kiss and keep on learning throughout life.
So I was curious: if such wear and tear is inevitable, how on earth does Mother Nature make sure we can keep our
chromosomes
intact?
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