Genome
in sentence
369 examples of Genome in a sentence
So now what we do is take a genome, we make maybe 50 copies of it, we cut all those copies up into little 50-base reads, and then we sequence them, massively parallel.
His pediatrician happens to have a background in clinical genetics and he has no idea what's going on, but he says, "Let's get this kid's
genome
sequenced."
The prospect of using the
genome
as a universal diagnostic is upon us today.
What I'd like you to consider is: What does it mean when these dots don't represent the individual bases of your genome, but they connect to genomes all across the planet?
Do you really want to elect a president whose
genome
suggests cardiomyopathy?
So imagine if my
genome
were De-identified, sitting in software, And a third cousin's
genome
was also sitting there, and there was software that could compare the two and make these associations.
Except genomics is a lens on biology through the window of the sequence of bases in the human
genome.
Here, instead of through the lens of a genome, through the lens of digitized pieces of the historical record.
So it meant that if you were a scientist who wanted to work on the human genome, you had to agree to abide by these principles.
But the human
genome
is just a tiny, tiny fraction of all scientific knowledge.
I spoke with one bioinformatician who told me that he'd been "sitting on the
genome
of an entire species for more than a year."
It was the sequencing for the first time of the human
genome.
We didn't sequence his
genome.
When it winds up its genome, divides into two cells and unwinds again, why does it not turn into an eye, into a liver, as it has all the genes necessary to do this?
Now this may look like a bunch of dots to you, but each one of these individual dots is actually a unique piece of the human
genome
that we spotted down on glass.
This has roughly 60,000 elements on it, so we repeatedly measure various genes of the 25,000 genes in the
genome.
And remember that we've assayed all the 25,000 genes in the
genome
and have all of that data available.
One other thing you can do with such a thing is you can, because it's a pattern matching exercise, because there's unique fingerprint, we can actually scan through the entire
genome
and find other proteins that show a similar fingerprint.
So if you're in drug discovery, for example, you can go through an entire listing of what the
genome
has on offer to find perhaps better drug targets and optimize.
Do you want to know how powerfully encoded fairness is in the human
genome?
And from these extracts, we can reconstruct the human
genome
at different points in time and look for changes that might be related to adaptations, risk factors and inherited diseases.
The most important health challenges today are not caused by simple mutations in our genome, but rather result from a complex and dynamic interplay between genetic variation, diet, microbes and parasites and our immune response.
And in order to understand these diseases, we need to move past studies of the human
genome
alone and towards a more holistic approach to human health in the past.
And as you're thinking about these two guys sequencing a human
genome
in 2000 and the Public Project sequencing the human
genome
in 2000, then you don't hear a lot, until you hear about an experiment last year in China, where they take skin cells from this mouse, put four chemicals on it, turn those skin cells into stem cells, let the stem cells grow and create a full copy of that mouse.
The cost of sequencing the human
genome
is dropping precipitously.
And I'd like to submit to you that we have sequenced the human genome, we know everything about the sequence of the gene, the language of the gene, the alphabet of the gene, But we know nothing, but nothing, about the language and alphabet of form.
And we did this because we think that it's actually going to allow us to realize the potential, the promise, of all of the sequencing of the human genome, but it's going to allow us, in doing that, to actually do clinical trials in a dish with human cells, not animal cells, to generate drugs and treatments that are much more effective, much safer, much faster, and at a much lower cost.
But even with that, there still was another big hurdle, and that actually brings us back to the mapping of the human genome, because we're all different.
We know from the sequencing of the human
genome
that it's shown us all of the A's, C's, G's and T's that make up our genetic code, but that code, by itself, our DNA, is like looking at the ones and zeroes of the computer code without having a computer that can read it.
By the end of this year, we'll be able to sequence the three million bits of information in your
genome
in less than a day and for less than 1,000 euros.
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