Virus
in sentence
1445 examples of Virus in a sentence
After all, there are no physical indications you have the
virus.
And I was lucky as in, there were these physical symptoms that let me know, hey, something is wrong, and it let me detect the
virus
pretty early.
When a
virus
invades a bacterium, Cas proteins cut out a segment of the viral DNA to stitch into the bacterium’s CRISPR region, capturing a chemical snapshot of the infection.
The resulting complexes act like scouts, latching onto free-floating genetic material and searching for a match to the
virus.
If the
virus
invades again, the scout complex recognizes it immediately, and Cas9 swiftly destroys the viral DNA.
Double strand again, but inside them, they're infected with a
virus
that has a nice, long, single-stranded genome that we can fold like a piece of paper.
So when a bacterium encounters a
virus
for the first time, it can store a small snippet of that
virus'
s DNA for use as a program to direct the CRISPR scissors to cut that viral DNA sequence during a future infection.
Cutting a
virus'
s DNA messes up the function of the cut viral gene, and therefore disrupts the
virus'
s life cycle.
For example, a collaborative team of scientists led by Luke Koblan and Jon Levy, two additional students in my lab, recently used a
virus
to deliver that second base editor into a mouse with progeria, changing that disease-causing T back into a C and reversing its consequences at the DNA, RNA and protein levels.
In some cases, and in fact in most cases in one year, this flu was caused by a new
virus
to us, or newly identified by us, called Israeli Acute Paralysis
virus.
But we think this
virus
is pretty ubiquitous.
Some block HIV’s access into immune cells, and others work by stopping the
virus
itself from replicating.
It’s based on the idea that someone with HIV who takes ARV’s can lower the
virus
level in their bodies until it becomes undetectable.
That doesn’t mean the
virus
is gone; it could still be lurking within cells, ready to reactivate if treatment stops.
In the period from 1996 to 2017 we almost halved the number of new HIV infections, and for the millions of people who still live with the virus, ARV treatments enable most to lead long and healthy lives.
But the consequence of this constant surveillance is that our bodies treat helpful implants, like insulin pumps, with the same suspicion as they would a harmful
virus
or bacteria.
To make better vaccines, we've designed protein particles to which we can fuse proteins from pathogens, like this blue protein here, from the respiratory
virus
RSV.
To make vaccine candidates that are literally bristling with the viral protein, we find that such vaccine candidates produce a much stronger immune response to the
virus
than any previous vaccines that have been tested.
But my favorite example has to be the global response to the SARS epidemic in 2003, 2004, which relied on worldwide access to the full gene sequence of the SARS
virus.
You're looking at the outside shell of the virus, and the yellow color here are those parts of the
virus
that are evolving very, very fast, and the blue parts are not evolving very fast.
And I'm coloring these small windows blue if another
virus
shares an identical sequence in its genome to that
virus.
And if spots light up, we know there's a certain
virus
in there.
That's what one of these chips really looks like, and these red spots are, in fact, signals coming from the
virus.
And each spot represents a different family of
virus
or species of
virus.
And then we did respiratory syncytial
virus.
And so we're getting unique signatures, a fingerprint for each
virus.
And Kaposi's sarcoma-associated herpes
virus
gives a nice signature down here.
And so it is not any one stripe or something that tells me I have a
virus
of a particular type here; it's the barcode that in bulk represents the whole thing.
You can imagine building up some library, whether real or virtual, of fingerprints of essentially every
virus.
It could have lots of bacteria, it could have more than one virus, and it certainly has host genetic material.
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