Spinal in sentence

197 examples of Spinal in a sentence

This was more than 10 years ago, but ever since, my laboratory has followed the pragmatic approach to recovery after spinal cord injury.

And my first step in this direction was to develop a new model of spinal cord injury that would more closely mimic some of the key features of human injury while offering well-controlled experimental conditions.

They completely interrupt the communication between the brain and the spinal cord, thus leading to complete and permanent paralysis of the leg.

It turned out that more than 100 years of research on spinal cord physiology, starting with the Nobel Prize Sherrington, had shown that the spinal cord, below most injuries, contained all the necessary and sufficient neural networks to coordinate locomotion, but because input from the brain is interrupted, they are in a nonfunctional state, like kind of dormant.

The engine is the spinal cord.

My idea: Replace this missing input to provide the spinal cord with the kind of intervention that the brain would deliver naturally in order to walk.

For this, I leveraged 20 years of past research in neuroscience, first to replace the missing fuel with pharmacological agents that prepare the neurons in the spinal cord to fire, and second, to mimic the accelerator pedal with electrical stimulation.

So here imagine an electrode implanted on the back of the spinal cord to deliver painless stimulation.

It took many years, but eventually we developed an electrochemical neuroprosthesis that transformed the neural network in the spinal cord from dormant to a highly functional state.

Here what I call "the spinal brain" cognitively processes sensory information arising from the moving leg and makes decisions as to how to activate the muscle in order to stand, to walk, to run, and even here, while sprinting, instantly stand if the treadmill stops moving.

Let me summarize: The rat received a paralyzing lesion of the spinal cord.

The electrochemical neuroprosthesis enabled a highly functional state of the spinal locomotor networks.

This is the first recovery ever observed of voluntary leg movement after an experimental lesion of the spinal cord leading to complete and permanent paralysis.

We did not aim to repair the spinal cord, yet we were able to promote one of the more extensive remodeling of axonal projections ever observed in the central nervous system of adult mammal after an injury.

This is certainly not a cure for spinal cord injury, but I begin to believe that this may lead to an intervention to improve recovery and people's quality of life.

Imagine a person just suffered a spinal cord injury.

After a few weeks of recovery, we will implant a programmable pump to deliver a personalized pharmacological cocktail directly to the spinal cord.

At the same time, we will implant an electrode array, a sort of second skin covering the area of the spinal cord controlling leg movement, and this array is attached to an electrical pulse generator that delivers stimulations that are tailored to the person's needs.

My hope here is to be able to create the personalized condition to boost the plasticity of the brain and the spinal cord.

And this is a radically new concept that may apply to other neurological disorders, what I termed "personalized neuroprosthetics," where by sensing and stimulating neural interfaces, I implanted throughout the nervous system, in the brain, in the spinal cord, even in peripheral nerves, based on patient-specific impairments.

What are the muscles doing, and how are they controlled by the spinal cord?

So we model the missing biological limb, and we've discovered what reflexes occurred, how the reflexes of the spinal cord are controlling the muscles.

What we've done, then, is we modulate the sensitivity of the reflex, the modeled spinal reflex, with the neural signal, so when I relax my muscles in my residual limb, I get very little torque and power, but the more I fire my muscles, the more torque I get, and I can even run.

In those visits to the emergency room, I had two CAT scans, I had a needle placed in the lower part of my back to collect spinal fluid, I had nearly a dozen blood tests.

So, sitting by his bed, I began to research why, after this period they call spinal shock, there's no recovery, there's no therapy, there's no cure, there's no hope.

MP: You see, spinal cord injury strikes at the very heart of what it means to be human.

My research taught us that we needed to remind Mark's damaged and dormant spinal cord of its upright, standing, running form, and we found San Francisco-based engineers at Ekso Bionics, who created this robotic exoskeleton that would allow Mark to stand and walk in the lab that we started to build in Dublin.

Using electrical stimulation of the spinal cord, a number of subjects have been able to stand, and because of that, regain some movement and feeling and most importantly, to regain some of the body's internal functions that are designed to keep us alive and to make that life a pleasure.

Electrical stimulation of the spinal cord, we think, is the first meaningful therapy ever for paralyzed people.

So we created our first collaboration, and the moment when we combined the electrical stimulation of Mark's spinal cord, as he walked in his robotic exoskeleton, was like that moment when Iron Man plugs the mini arc reactor into his chest and suddenly he and his suit become something else altogether.

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