Sleep
in sentence
1612 examples of Sleep in a sentence
Another connection between loss of
sleep
is weight gain.
If you
sleep
around about five hours or less every night, then you have a 50 percent likelihood of being obese.
Well,
sleep
loss seems to give rise to the release of the hormone ghrelin, the hunger hormone.
So, if you're acutely stressed, not a great problem, but it's sustained stress associated with
sleep
loss that's the problem.
So there's a whole raft of things associated with
sleep
loss that are more than just a mildly impaired brain, which is where I think most people think that
sleep
loss resides.
So at this point in the talk, this is a nice time to think, "Well, do you think on the whole I'm getting enough sleep?"
Who feels that they're getting enough
sleep
here?
So most of us, of course, ask the question, "How do I know whether I'm getting enough sleep?"
We need eight hours of
sleep
a night.
The
sleep
demands of the aged do not go down.
Essentially,
sleep
fragments and becomes less robust, but
sleep
requirements do not go down.
So for the last few minutes, what I want to do is change gears and talk about some really new, breaking areas of neuroscience, which is the association between mental health, mental illness and
sleep
disruption.
We've known for 130 years that in severe mental illness, there is always, always
sleep
disruption, but it's been largely ignored.
In the 1970s, when people started to think about this again, they said, "Yes, well, of course you have
sleep
disruption in schizophrenia, because they're on antipsychotics.
It's the antipsychotics causing the
sleep
problems," ignoring the fact that for a hundred years previously,
sleep
disruption had been reported before antipsychotics.
Several groups are studying conditions like depression, schizophrenia and bipolar and what's going on in terms of
sleep
disruption.
And some had no ability to regulate their
sleep
by the light-dark cycle.
And the really exciting news is that mental illness and
sleep
are not simply associated, but they are physically linked within the brain.
The neural networks that predispose you to normal sleep, give you normal sleep, and those that give you normal mental health, are overlapping.
Well, genes that have been shown to be very important in the generation of normal sleep, when mutated, when changed, also predispose individuals to mental health problems.
The first was that
sleep
disruption actually precedes certain types of mental illness, and we've shown that in those young individuals who are at high risk of developing bipolar disorder, they already have a
sleep
abnormality prior to any clinical diagnosis of bipolar.
The other bit of data was that
sleep
disruption may actually exacerbate, make worse, the mental illness state.
My colleague Dan Freeman has used a range of agents which have stabilized
sleep
and reduced levels of paranoia in those individuals by 50 percent.
In terms of the neuroscience, by understanding these two systems, we're really beginning to understand how both
sleep
and mental illness are generated and regulated within the brain.
The second area is that if we can use
sleep
and
sleep
disruption as an early warning signal, then we have the chance of going in.
And the third, which I think is the most exciting, is that we can think of the
sleep
centers within the brain as a new therapeutic target.
Stabilize
sleep
in those individuals who are vulnerable, we can certainly make them healthier, but also alleviate some of the appalling symptoms of mental illness.
What I started by saying is: Take
sleep
seriously.
Our attitudes toward
sleep
are so very different from a pre-industrial age, when we were almost wrapped in a duvet.
If you have good sleep, it increases your concentration, attention, decision-making, creativity, social skills, health.
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