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Protein in sentence

339 examples of Protein in a sentence

But we quickly encountered an incredible problem; namely, there is no protein that's known to convert A into G or T into C in DNA.
Given the absence of a naturally occurring protein that performs the necessary chemistry, we decided we would evolve our own protein in the laboratory to convert A into a base that behaves like G, starting from a protein that performs related chemistry on RNA.
We set up a Darwinian survival-of-the-fittest selection system that explored tens of millions of protein variants and only allowed those rare variants that could perform the necessary chemistry to survive.
We ended up with a protein shown here, the first that can convert A in DNA into a base that resembles G.
And when we attached that protein to the disabled CRISPR scissors, shown in blue, we produced the second base editor, which converts As into Gs, and then uses the same strand-nicking strategy that we used in the first base editor to trick the cell into replacing the nonedited T with a C as it remakes that nicked strand, thereby completing the conversion of an A-T base pair to a G-C base pair.
For example, a collaborative team of scientists led by Luke Koblan and Jon Levy, two additional students in my lab, recently used a virus to deliver that second base editor into a mouse with progeria, changing that disease-causing T back into a C and reversing its consequences at the DNA, RNA and protein levels.
Alzheimer’s disease starts when a protein that should be folded up properly misfolds into a kind of demented origami.
So one approach we’re taking is to try to design drugs that function like molecular Scotch tape, to hold the protein into its proper shape.
Interestingly enough, other neurologic diseases which affect very different parts of the brain also show tangles of misfolded protein, which suggests that the approach might be a general one, and might be used to cure many neurologic diseases, not just Alzheimer’s disease.
For 3 billion people around the world, seafood provides a significant source of protein and nutrition.
We have genomes, we have DNA, DNA is transcripted into RNA, RNA translates that into a protein, and that's how we come to be.
But when they get hydrated and they bond to each other, they create a stronger molecule, a stronger protein we call gluten.
Each protein folds to its characteristic shape each time, and the folding process takes just a fraction of a second.
The shapes of proteins, and hence their remarkable functions, are completely specified by the sequence of amino acids in the protein chain.
Each gene encodes the amino acid sequence of a single protein.
The translation between these amino acid sequences and the structures and functions of proteins is known as the protein folding problem.
It's a very hard problem because there's so many different shapes a protein can adopt.
In a similar way, we've been working for a number of years to uncover the fundamental principles of protein folding and encoding those principles in the computer program called Rosetta.
Once we've designed the new protein, we encode its amino acid sequence in a synthetic gene.
We have to make a synthetic gene because since the protein is completely new, there's no gene in any organism on earth which currently exists that encodes it.
Our advances in understanding protein folding and how to design proteins, coupled with the decreasing cost of gene synthesis and the Moore's law increase in computing power, now enable us to design tens of thousands of new proteins, with new shapes and new functions, on the computer, and encode each one of those in a synthetic gene.
I told you that nature uses an alphabet of 20 amino acids, and a typical protein is a chain of about 100 amino acids, so the total number of possibilities is 20 times 20 times 20, 100 times, which is a number on the order of 10 to the 130th power, which is enormously more than the total number of proteins which have existed since life on earth began.
And it's this unimaginably large space we can now explore using computational protein design.
Instead, with computational protein design, we can design new proteins to address these challenges today.
Our audacious idea is to bring biology out of the Stone Age through technological revolution in protein design.
To make better vaccines, we've designed protein particles to which we can fuse proteins from pathogens, like this blue protein here, from the respiratory virus RSV.
To make vaccine candidates that are literally bristling with the viral protein, we find that such vaccine candidates produce a much stronger immune response to the virus than any previous vaccines that have been tested.
These advances are the beginning of the protein design revolution.
Our goal is to build the Bell Laboratories of protein design.
We are seeking to attract talented scientists from around the world to accelerate the protein design revolution, and we'll be focusing on five grand challenges.
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