Protein in sentence

339 examples of Protein in a sentence

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana-Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.

Now, BRD4 is an interesting protein.

So we developed an idea, a rationale, that perhaps if we made a molecule that prevented the Post-it note from sticking by entering into the little pocket at the base of this spinning protein, then maybe we could convince cancer cells, certainly those addicted to this BRD4 protein, that they're not cancer.

We sent it to Oxford, England, where a group of talented crystallographers provided this picture, which helped us understand exactly how this molecule is so potent for this protein target.

Well as you know, genes, which are part of the DNA, they're instructions to make a protein that does something.

And the way that they're switched on is by a gene regulator protein called FOXO.

A FOXO is a protein that we found in these little, round worms to affect lifespan, and here it affects lifespan in people.

But in this case, there's already a drug called rapamycin that binds to the TOR protein and inhibits its activity.

CK: Ah, so the kinds of drugs I was talking about would not change the genes, they would just bind to the protein itself and change its activity.

So if you stop taking the drug, the protein would go back to normal.

But what seems so slow and graceful from the outside is really more like chaos inside, because cells control their shape with a skeleton of rigid protein fibers, and those fibers are constantly falling apart.

Spider silk is almost entirely protein.

To give you an idea of what a spider silk protein looks like, this is a dragline silk protein, it's just a portion of it, from the black widow spider.

And on the bottom, this is the repeat sequence for the egg case, or tubuliform silk protein, for the exact same spider.

Well if cancer can be caught early, enough such that someone can have their cancer taken out, excised with surgery, I don't care if it has this gene or that gene, or if it has this protein or that protein, it's in the jar.

A billion people depend on fish for their main source for animal protein.

And we thought it had something to do with this protein called AMP kinase, an energy protein.

So we ran all of these tests blocking the protein, and we saw this huge shift.

Well basically that means that this protein is changing from the sensitive cell to the resistant cell.

In fact, it means that if a patient comes in and they're resistant to this drug, then if we give them a chemical to block this protein, then we can treat them again with the same drug.

But see how much of the protein is still throughout the nucleus, even in the dividing cell.

It used to be like this thing that prevents me from doing all this stuff, that causes other kids to die, that causes everybody to be stressed, and now it’s a protein that is abnormal, that weakens the structure of cells.

That also doesn't even get into the whole protein extraction that we do from the ocean.

And this is a game where individuals can actually take a sequence of amino acids and figure out how the protein is going to fold.

And when these individuals went and looked at who was the best protein folder in the world, it wasn't an MIT professor, it wasn't a CalTech student, it was a person from England, from Manchester, a woman who, during the day, was an executive assistant at a rehab clinic and, at night, was the world's best protein folder.

These soybeans are being shipped to Europe and to China as animal feed, especially after the mad cow disease scare about a decade ago, where we don't want to feed animals animal protein anymore, because that can transmit disease.

And so by applying ancient DNA sequencing and protein mass spectrometry technologies to ancient dental calculus, we can generate immense quantities of data that then we can use to begin to reconstruct a detailed picture of the dynamic interplay between diet, infection and immunity thousands of years ago.

But one of the most popular ones involves green fluorescent protein.

Now green fluorescent protein, which oddly enough comes from a bioluminescent jellyfish, is very useful.

But it turns out that they're so useful to the immune system because they can recognize specific molecules, like, for example, the coat protein of a virus that's invading the body.

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