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Diseases in sentence

1608 examples of Diseases in a sentence

Grievous genetic diseases caused by point mutations are especially frustrating, because we often know the exact single-letter change that causes the disease and, in theory, could cure the disease.
But for most point mutations that cause genetic diseases, simply cutting the already-mutated gene won't benefit patients, because the function of the mutated gene needs to be restored, not further disrupted.
Like many scientists, I've dreamed of a future in which we might be able to treat or maybe even cure human genetic diseases.
But I saw the lack of a way to fix point mutations, which cause most human genetic diseases, as a major problem standing in the way.
Being a chemist, I began working with my students to develop ways on performing chemistry directly on an individual DNA base, to truly fix, rather than disrupt, the mutations that cause genetic diseases.
While base editors are too new to have already entered human clinical trials, scientists have succeeded in achieving a critical milestone towards that goal by using base editors in animals to correct point mutations that cause human genetic diseases.
And biologists have used base editors to probe the role of individual letters in genes associated with diseases such as cancer.
Two companies I cofounded, Beam Therapeutics and Pairwise Plants, are using base editing to treat human genetic diseases and to improve agriculture.
Additional work lies ahead before base editing can realize its full potential to improve the lives of patients with genetic diseases.
While many of these diseases are thought to be treatable by correcting the underlying mutation in even a modest fraction of cells in an organ, delivering molecular machines like base editors into cells in a human being can be challenging.
Unless we do something to prevent it, over the next 40 years we’re facing an epidemic of neurologic diseases on a global scale.
Interestingly enough, other neurologic diseases which affect very different parts of the brain also show tangles of misfolded protein, which suggests that the approach might be a general one, and might be used to cure many neurologic diseases, not just Alzheimer’s disease.
There’s also a fascinating connection to cancer here, because people with neurologic diseases have a very low incidence of most cancers.
Now, I had been working on other topics: the emergence of infectious diseases, which come out of the natural ecosystems of the Earth, make a trans-species jump, and get into humans.
Human saliva in particular mirrors the composition of our bodies’ proteins and hormones, and can give early-warning signals for certain cancers and infectious and autoimmune diseases.
We know our planet, we cure our diseases, we cook our food, we leave our planet.
It's also pretty clear that the bees sometimes catch other viruses or other flus, and so the question we're still struggling with, and the question that keeps us up at night, is why have the bees suddenly become so susceptible to this flu, and why are they so susceptible to these other diseases?
They produce massive amounts of waste, polluting the surrounding areas and potentially spreading diseases to wild species.
HIV has caused millions of deaths and is one of the most devastating diseases that humanity has ever known.
And I believe, as John Boyle put it, these diseases should be in history books and not in our communities.
We live longer, so new diseases are important.
In fact, many, many diseases we have struggled with for a long time, like cancer, we haven't been able to cure because we just don't understand how it works at the genomic level.
Throughout history, there had been many examples of diseases being associated with a smell.
And in fact, when you look at the sort of words used to describe diseases, you tend to find these words: rotting, foul, putrid or pungent.
This could completely revolutionise the way that we track the spread of diseases, the way that we target our control efforts and respond to disease outbreaks, ultimately helping to lead to the eradication of malaria, and even beyond malaria for other diseases that we already know have a smell.
Last year, hundreds of volunteer biology and chemistry researchers around the world worked together to sequence the genome of the parasite responsible for some of the developing world's worst diseases: African sleeping sickness, leishmaniasis and Chagas disease.
Why? Well there's only a few diseases that account for the vast majority of those deaths: diarrhea, pneumonia and malaria.
And by monitoring populations to quickly identify new outbreaks, they can develop vaccines and containment protocols to stop these deadly diseases.
And so either the immune system does not recognize the cancer as a problem, or it attacks a cancer and also our normal cells, leading to autoimmune diseases like colitis or multiple sclerosis.
So now there are many labs and physicians and scientists around the world who have tested CAR T cells across many different diseases, and understandably, we're all thrilled with the rapid pace of advancement.
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