Disease in sentence

3042 examples of Disease in a sentence

SB: Well, research on progeria has come so far in less than 15 years, and that just shows the drive that researchers can have to get this far, and it really means a lot to myself and other kids with progeria, and it shows that if that drive exists, anybody can cure any disease, and hopefully progeria can be cured in the near future, and so we can eliminate those 4,000 diseases that Francis was talking about.

It's such a rare disease, it would be hard for a company to justify spending hundreds of millions of dollars to generate a drug.

This is the 21st-century biology that you've been waiting for, and we have the chance to take that and turn it into something which will, in fact, knock out disease.

And by 2010, she hopes to eliminate this disease, which is really a scourge in the developing world.

We know, because in the mid-19th century, wonderful Victorian engineers installed systems of sewers and wastewater treatment and the flush toilet, and disease dropped dramatically.

But the humble latrine, or flush toilet, reduces disease by twice as much as just putting in clean water.

Six thousand children each year who would have previously died of this disease are cured.

If you want the really big numbers, look at these numbers for heart disease.

Heart disease used to be the biggest killer, particularly for men in their 40s.

AIDS, incredibly, has just been named, in the past month, a chronic disease, meaning that a 20-year-old who becomes infected with HIV is expected not to live weeks, months, or a couple of years, as we said only a decade ago, but is thought to live decades, probably to die in his '60s or '70s from other causes altogether.

And one in particular that you probably wouldn't know about, stroke, which has been, along with heart disease, one of the biggest killers in this country, is a disease in which now we know that if you can get people into the emergency room within three hours of the onset, some 30 percent of them will be able to leave the hospital without any disability whatsoever.

Now this is, of course, not a disease, per se.

Heart disease seems far more serious.

It's a little different than the way we think about brain disorders like Huntington's or Parkinson's or Alzheimer's disease where you have a bombed-out part of your cortex.

And it's important, if you try to model this, you can think about normal development as a loss of cortical mass, loss of cortical gray matter, and what's happening in schizophrenia is that you overshoot that mark, and at some point, when you overshoot, you cross a threshold, and it's that threshold where we say, this is a person who has this disease, because they have the behavioral symptoms of hallucinations and delusions.

If we waited until the heart attack, we would be sacrificing 1.1 million lives every year in this country to heart disease.

But they thought that, if you had a neurologic or psychiatric disease, it must be because you are possessed by an evil spirit.

There were some sites where one percent of all the skulls have these holes, and so you can see that neurologic and psychiatric disease is quite common, and it was also quite common about 7,000 years ago.

So when these neurons are in the motor circuit, you get dysfunction in the movement system, and you get things like Parkinson's disease.

When the malfunction is in a circuit that regulates your mood, you get things like depression, and when it is in a circuit that controls your memory and cognitive function, then you get things like Alzheimer's disease.

Now the first example I'm going to show you is a patient with Parkinson's disease, and this lady has Parkinson's disease, and she has these electrodes in her brain, and I'm going to show you what she's like when the electrodes are turned off and she has her Parkinson's symptoms, and then we're going to turn it on.

This boy is nine years old, perfectly normal until the age six, and then he started twisting his body, first the right foot, then the left foot, then the right arm, then the left arm, then the trunk, and then by the time he arrived, within the course of one or two years of the disease onset, he could no longer walk, he could no longer stand.

We did not know what operation to do, where to go in the brain, but on the basis of our results in Parkinson's disease, we reasoned, why don't we try to suppress the same area in the brain that we suppressed in Parkinson's disease, and let's see what happens?

I've shown you that we can use deep brain stimulation to treat the motor system in cases of Parkinson's disease and dystonia.

We're going to do this in people that have cognitive deficits, and we've chosen to treat patients with Alzheimer's disease who have cognitive and memory deficits.

As you know, this is the main symptom of early onset Alzheimer's disease.

So we've placed electrodes within this circuit in an area of the brain called the fornix, which is the highway in and out of this memory circuit, with the idea to see if we can turn on this memory circuit, and whether that can, in turn, help these patients with Alzheimer's disease.

Now it turns out that in Alzheimer's disease, there's a huge deficit in glucose utilization in the brain.

Twenty percent of all the glucose in your body is used by the brain, and as you go from being normal to having mild cognitive impairment, which is a precursor for Alzheimer's, all the way to Alzheimer's disease, then there are areas of the brain that stop using glucose.

So the lights are out in parts of the brain in patients with Alzheimer's disease, and the question is, are the lights out forever, or can we turn the lights back on?

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