Cancers
in sentence
163 examples of Cancers in a sentence
Yet lessons learned in dealing with exotic species, combined with recent mathematical models of the evolutionary dynamics of tumors, indicate that eradicating most
cancers
may be impossible.
Recent research suggests that efforts to eliminate
cancers
may actually hasten the emergence of resistance and tumor recurrence, thus reducing a patient’s chances of survival.
Sophisticated biopharmaceuticals – drugs typically used in patients with extremely advanced
cancers
– are also multiplying.
Many people in poor countries die from
cancers
that are preventable or treatable in wealthier societies, but they often succumb to other scourges as well, such as infectious diseases.
Many
cancers
are likely caused by chronic viral infections, another reason that it is surely more sensible to attack infectious diseases by improving access to clean water, basic sanitation, antibiotics, and vaccines than it is to build radiotherapy facilities.
Another example is cervical cancers, many of which can be prevented by vaccines against human papilloma virus.
And acetic acid can be used to visualize cervical cancers, which can then be treated with cryotherapy (freezing).
And there is no credible evidence that low-grade prostate cancer uniformly progresses to higher-grade cancers, so early treatment is not essential.
As evidence tilts the balance away from widespread PSA testing, a new screening test or biomarker is urgently needed that can distinguish effectively between potentially life-threatening prostate
cancers
and less dangerous forms.
For example, mutations, or defects, at specific molecular locations in human DNA were found to be responsible for some cancers, raising the hope of developing successful therapies tailored to individual patients.
Women with the “wrong” version of these genes have a heightened risk of developing breast cancer (up to 85%, against the normal 12%, although the genes account for only a minority of breast cancers).
Thus, for example, the report on drinking water predicted the frequency of bladder
cancers
that would eventually occur in a population exposed to levels of five, 10, or 20 parts per billion of arsenic.
This is not just ancient history, irrelevant in the era of molecular biology: naturally derived compounds, such as taxol, still provide some of the most promising avenues for the treatment of
cancers
and other diseases.
The Dartmouth researchers found that, of the estimated 138,000 breast
cancers
detected annually in the US, the test did not help 120,000-134,000 of the afflicted women.
The
cancers
either were growing so slowly that they did not pose a problem, or they would have been treated successfully if discovered clinically later (or they were so aggressive that little could be done).
And researchers are identifying genetic variations that influence the effects of drugs, allowing safer and more effective administration of medication to manage pain and treat some cancers, as well as cardiovascular and psychiatric diseases.
Taking these developments a step further, the Precision Medicine Initiative, launched in the US last year, is pursuing innovative trials of targeted drugs for adult and pediatric cancers, introducing customized combination therapies, and honing its understanding of drug resistance.
If this continues, the result will be animal suffering on an even greater scale than now exists in the West, as well as more environmental damage and a rise in heart disease and
cancers
of the digestive system.
But, whatever the reason (or reasons) for the rise in their occurrence, we also know that between 5% and 10% of breast
cancers
are due to an inherited defect that affects the BRCA1 or BRCA2 genes.
As antibiotic resistance continues to undermine our ability to treat cancers, transplant organs, and implant prosthesis, these figures will only rise.
There would be thousands of spontaneous abortions and more than 300,000 later
cancers.
A recent study showed that a few years of smoking can have this effect, making smokers more susceptible to a variety of
cancers.
Another example of changing global health needs is the stunningly fast increase of heart disease, cancers, and other noncommunicable diseases (NCDs) in low- and middle-income countries.
Despite much higher rates of obesity in high-income countries, premature death and disability from heart disease, cancers, and other NCDs have declined substantially.
The COG conducts research across the spectrum of
cancers
that afflict children, and has approximately 100 clinical trials underway around the world.
With an emerging infrastructure in place for cooperative research, sustained improvement in outcomes partly reflected an ever-increasing understanding that childhood
cancers
are diverse.
Recognition of this diversity led to the study of different treatment regimens in different sub-populations of children with pathologically similar
cancers.
Children with high-risk
cancers
who receive dose-intensive chemotherapy have a greater than 80% chance of experiencing at least one severe, life-threatening, or fatal drug-related toxic event over the course of their treatment.
The late effects of cancer treatment include permanent organ and tissue damage, hormonal and reproductive dysfunction, and second
cancers.
The powerful research tools that we now have to uncover the underlying basis of childhood
cancers
could fundamentally change how we treat children with these dreaded diseases.
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