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Amyloid in sentence

21 examples of Amyloid in a sentence

During the business of communicating information, in addition to releasing neurotransmitters like glutamate into the synapse, neurons also release a small peptide called amyloid beta.
Normally, amyloid beta is cleared away metabolized by microglia, the janitor cells of our brains.
While the molecular causes of Alzheimer's are still debated, most neuroscientists believe that the disease begins when amyloid beta begins to accumulate.
Too much is released, or not enough is cleared away, and the synapse begins to pile up with amyloid beta.
And when this happens, it binds to itself, forming sticky aggregates called amyloid plaques.
This initial step into the disease, this presence of amyloid plaques accumulating, can already be found in your brains.
We think it takes at least 15 to 20 years of amyloid plaque accumulation before it reaches a tipping point, then triggering a molecular cascade that causes the clinical symptoms of the disease.
So what happens when amyloid plaques accumulate to this tipping point?
Many scientists are betting big on the simplest solution: keep amyloid plaques from reaching that tipping point, which means that drug discovery is largely focused on developing a compound that will prevent, eliminate, or reduce amyloid plaque accumulation.
Think of amyloid plaques as a lit match.
Even before scientists sort this out, this information is actually really good news for us, because it turns out that the way we live can influence the accumulation of amyloid plaques.
You're not a spring chicken anymore, so you've accumulated some amyloid plaques with age.
If you're like Alice in "Still Alice," you've inherited a rare genetic mutation that cranks out amyloid beta, and this alone will tip your scale arm to the ground.
For example, APOE4 is a gene variant that increases amyloid, but you can inherit a copy of APOE4 from mom and dad and still never get Alzheimer's, which means that for most of us, our DNA alone does not determine whether we get Alzheimer's.
A single night of sleep deprivation leads to an increase in amyloid beta.
And amyloid accumulation has been shown to disrupt sleep, which in turn causes more amyloid to accumulate.
Aerobic exercise has been shown in many studies to decrease amyloid beta in animal models of the disease.
Let's imagine that your amyloid plaques have reached that tipping point.
They’re also revolutionizing the diagnosis of Alzheimer’s disease by allowing doctors to see amyloid, the telltale protein buildup that otherwise couldn’t be confirmed without an autopsy.
The research found that amyloid-beta – the substance that clumps together and forms amyloid plaques – becomes depleted in the cerebrospinal fluid around the brain as long as 25 years before the onset of dementia.
Even if accurate early prediction of Alzheimer’s eventually is achieved, there are currently no drugs available to prevent or cure it before the amyloid plaques start destroying the mind.