Proteins
in sentence
328 examples of Proteins in a sentence
Proteins, some of which you see inside a cell here, carry out essentially all the important functions in our bodies.
Proteins
digest your food, contract your muscles, fire your neurons and power your immune system.
Proteins
are linear chains of building blocks called amino acids.
And it's the shapes of
proteins
which enable them to carry out their remarkable biological functions.
The shapes of proteins, and hence their remarkable functions, are completely specified by the sequence of amino acids in the protein chain.
The genes in your genome specify the amino acid sequences of your
proteins.
The translation between these amino acid sequences and the structures and functions of
proteins
is known as the protein folding problem.
Because of this complexity, humans have only been able to harness the power of
proteins
by making very small changes to the amino acid sequences of the
proteins
we've found in nature.
We can now design completely new
proteins
from scratch on the computer.
Our advances in understanding protein folding and how to design proteins, coupled with the decreasing cost of gene synthesis and the Moore's law increase in computing power, now enable us to design tens of thousands of new proteins, with new shapes and new functions, on the computer, and encode each one of those in a synthetic gene.
Once we have those synthetic genes, we put them into bacteria to program them to make these brand-new
proteins.
We then extract the
proteins
and determine whether they function as we designed them to and whether they're safe.
It's exciting to be able to make new proteins, because despite the diversity in nature, evolution has only sampled a tiny fraction of the total number of
proteins
possible.
I told you that nature uses an alphabet of 20 amino acids, and a typical protein is a chain of about 100 amino acids, so the total number of possibilities is 20 times 20 times 20, 100 times, which is a number on the order of 10 to the 130th power, which is enormously more than the total number of
proteins
which have existed since life on earth began.
Now the
proteins
that exist on earth evolved to solve the problems faced by natural evolution.
If we had a million years to wait, new
proteins
might evolve to solve those challenges.
Instead, with computational protein design, we can design new
proteins
to address these challenges today.
We've already shown that we can design new
proteins
with new shapes and functions.
To make better vaccines, we've designed protein particles to which we can fuse
proteins
from pathogens, like this blue protein here, from the respiratory virus RSV.
We've also designed new
proteins
to break down gluten in your stomach for celiac disease and other
proteins
to stimulate your immune system to fight cancer.
First, by taking
proteins
from flu strains from around the world and putting them on top of the designed protein particles I showed you earlier, we aim to make a universal flu vaccine, one shot of which gives a lifetime of protection against the flu.
A few years later, when I moved to Harvard first as a sabbatical, I became interested in another type of network: that time, the networks within ourselves, how the genes and the
proteins
and the metabolites link to each other and how they connect to disease.
You can go out and get your proteins, your RNA, your DNA, whatever.
Human flu viruses are covered in
proteins
adapted to bind with matching receptors on human respiratory cells.
Literally, think of
proteins
as subroutines that you can string together to execute a program.
And the ribosome here is another little computer that helps in the translation of the
proteins.
What
proteins
are involved in signal transduction and also related to pyramidal neurons?
We need to get proteins, we need to get micronutrients, we need to get vitamins.
This condition is actually an autoimmune disease in which autoantibodies target natively produced proteins, some of which are secreted by cartilage cells.
This leads to the flood of enzymes and degradation seen in osteoarthritis, but is driven by different inflammatory
proteins
called cytokines.
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