Closed in example sentence
Three giant sabretooth tigers(..created in a laboratory from mitochondrial DNA, a "genetic breakthrough" derived from fossil material)are on the rampage accidentally set free through a series of events(such as a computer geek's introduced virus in order to unlock security measures keeping the resort novelty shops closed during construction & a security guard's leaving a gate open while searching for the missing page from a porn mag that flew away in the breeze)that threaten the lives of those it comes in contact with.