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Misfortune in example sentence

He could see quite well, though, that there were more reasons than consideration for him that made it difficult for them to move, it would have been quite easy to transport him in any suitable crate with a few air holes in it; the main thing holding the family back from their decision to move was much more to do with their total despair, and the thought that they had been struck with a misfortune unlike anything experienced by anyone else they knew or were related to.
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