You see, you can go ahead and create new pandemics, and the researchers who did this were so proud of their accomplishments, they wanted to publish it openly so that everybody could see this and get access to this information.

Their fitness for creating pandemics we are unaware of, but we are ripe for zoonotic-borne, emerging communicable diseases.

It's increasingly irrelevant to the kinds of decisions we face that have to do with global pandemics, a cross-border problem; with HIV, a transnational problem; with markets and immigration, something that goes beyond national borders; with terrorism, with war, all now cross-border problems.

With your money, you can support organizations that focus on these risks, like the Nuclear Threat Initiative, which campaigns to take nuclear weapons off hair-trigger alert, or the Blue Ribbon Panel, which develops policy to minimize the damage from natural and man-made pandemics, or the Center for Human-Compatible AI, which does technical research to ensure that AI systems are safe and reliable.

All of the grand challenges that we face today, like climate change and human rights and demographics and terrorism and pandemics and narco-trafficking and human slavery and species loss, I could go on, we're not making an awful lot of progress against an awful lot of those challenges.

It is whether the US can work with an inner core of allies to promote democracy and human rights while cooperating with a broader set of states to manage the rules-based international institutions needed to face transnational threats such as climate change, pandemics, cyber-attacks, terrorism, and economic instability.

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