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For example, we were stuck for a year trying to understand the intricate biochemical networks inside our cells, and we said, "We are deeply in the cloud," and we had a playful conversation where my student Shai Shen Orr said, "Let's just draw this on a piece of paper, this network," and instead of saying, "But we've done that so many times and it doesn't work," I said, "Yes, and let's use a very big piece of paper," and then Ron Milo said, "Let's use a gigantic architect's blueprint kind of paper, and I know where to print it," and we printed out the network and looked at it, and that's where we made our most important discovery, that this complicated network is just made of a handful of simple, repeating interaction patterns like motifs in a stained glass window.
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